OCT4B1 Suppression down Regulated BCL2 Gene Family Expression in Human Tumor Cell Lines
نویسنده
چکیده
1Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 2Departments of Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 3Departments of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 4Departments of Biochemistry, School of Medicine, jiroft University of Medical Sciences, Jiroft, Iran
منابع مشابه
Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines
Objective(s): The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. Materials and Met...
متن کاملThe Relationship between the Expression of Small Heat-Shock Proteins and Suppression of OCT4B1
Background: OCT4B1, a variant of OCT4, is expressed in both cancer cells and tissues. This variant has a main role in the regulation of both apoptotic and stress (heat-shock proteins) pathways. The aim of this study was to investigate the effects of OCT4B1 silencing on the expression of small heat-shock proteins (sHSPs)in three human tumor cell lines. Methods:...
متن کاملDown-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines.
OBJECTIVES The OCT4B1, as one of OCT4 variants, is expressed in cancer cell lines and tissues more than other variants and plays an important role in apoptosis and stress (heat shock protein) pathways. The present study was designed to determine the effects of OCT4B1 silencing on expressional profile of HSP40 gene family expression in three different human tumor cell lines. MATERIALS AND METH...
متن کاملRole of crocin in several cancer cell lines: An updated review
Cancer is a major public health problem worldwide. The most important considerable features of cancer cells are uncontrolled proliferation, up-regulated differentiation, and immortality. Crocin, as a bioactive compound of saffron and as a water-soluble carotenoid has radical scavenging, anti-hyperlipidemia, memory improving, and inhibition of tumor growth effects. The present review was designe...
متن کاملBET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
BET family proteins are epigenetic regulators known to control expression of genes involved in cell growth and oncogenesis. Selective inhibitors of BET proteins exhibit potent anti-proliferative activity in a number of hematologic cancer models, in part through suppression of the MYC oncogene and downstream Myc-driven pathways. However, little is currently known about the activity of BET inhibi...
متن کامل